Newcastle boss Steve Bruce says it is “morally wrong” for football to continue amid increasing coronavirus outbreaks at clubs.
The Magpies were the first team to have a Premier League match postponed this season, but more than 60 games in England have been called off.
Aston Villa and Derby are also having to field U23 teams in the FA Cup.
“Financially its right to play on, but for me, morally, it’s probably wrong,” said Bruce.
“I understand people want to see a game of football but we are just as vulnerable as everybody else.
“The speed which it hit our club within hours of each other, it was quite incredible how it rips through you. It’s difficult to contain and stop and it leaves people sick.”
Newcastle captain Jamaal Lascelles and winger Allan Saint-Maximin have both been suffering with the virus for about six weeks, and Bruce said one of his staff was almost hospitalised.
His team, who face a trip to holders Arsenal in the FA Cup third round on Saturday, had their game at Aston Villa postponed in December because of a sharp rise in cases at the North East club.
Their training ground was also closed for more than a week as they tried to contain the virus.
Villa, who host Liverpool in the FA Cup yesterday, have now also had to shut down their training ground and will field a side made up mainly from their under-23 set-up, while Derby County’s first-team squad, including manager Wayne Rooney, will miss their FA Cup tie at Chorley today because of an outbreak.
Bruce, who will welcome back defender Lascelles into his squad for the game at Arsenal, believes ties should be postponed instead of going ahead with weakened teams.